The significance of adopting mobile-friendly practices in web design lies in the increasing use of mobile devices for internet browsing. A responsive website ensures an optimal viewing experience across various screen sizes, enhancing user engagement and satisfaction. Mobile-friendly designs improve site loading times and readability, which are crucial for retaining visitors. Furthermore, search engines like Google prioritize mobile-optimized websites in rankings, directly impacting traffic and user acquisition. By adapting to mobile trends, businesses can reach broader audiences and provide seamless experiences, ultimately driving growth.