The significance of 2FA (two-factor authentication) lies in its ability to enhance security by requiring users to provide two forms of verification before accessing accounts. This typically involves something the user knows (like a password) and something they have (like a mobile device for an authentication code). By implementing 2FA, organizations reduce the risk of unauthorized access and account breaches significantly. It adds an additional layer of security, ensuring that even if passwords are compromised, unauthorized users cannot easily access sensitive information, thereby bolstering overall account protection.