The main challenge of maintaining data integrity in organizations is ensuring that the data remains accurate, consistent, and trustworthy throughout its lifecycle. Factors like human error, data corruption, cyber threats, and system failures can compromise data integrity. Additionally, integrating data from various sources poses compatibility and synchronization issues, making it difficult to maintain a single source of truth. Organizations must implement robust data governance policies, regular audits, and security measures to mitigate these risks and safeguard the reliability of their data assets.