The record for the most points scored in a single NBA game is held by Wilt Chamberlain, who scored an astounding 100 points on March 2, 1962. This remarkable achievement took place while he was playing for the Philadelphia Warriors against the New York Knicks in Hershey, Pennsylvania. Chamberlain’s performance remains one of the most iconic moments in sports history, showcasing his incredible scoring ability and dominance on the court, a record that stands unchallenged to this day.