The organelle responsible for detoxifying certain chemicals in the liver is the smooth endoplasmic reticulum (SER). This organelle plays a critical role in the metabolism of drugs, toxins, and various biomolecules. The SER contains enzymes that facilitate the conversion of lipid-soluble compounds into more water-soluble forms, allowing for easier excretion from the body. Additionally, the smooth ER is involved in the synthesis of lipids and steroid hormones. This detoxifying capability is essential for maintaining cellular health and overall homeostasis in the organism.