The significance of DNA replication in cell division lies in its role in ensuring genetic material is accurately copied and distributed to daughter cells. Prior to a cell dividing through processes like mitosis or meiosis, DNA must be replicated so that each new cell receives a complete set of genetic instructions. Any errors during replication can lead to mutations, which can have various consequences, including cancer or genetic disorders. Thus, DNA replication is fundamental to maintaining genomic integrity and enabling organismal growth and reproduction.