The myth of Sisyphus symbolizes the themes of futility and persistence through his eternal punishment of rolling a boulder uphill only for it to roll back down each time he reaches the summit. This narrative reflects the human condition, emphasizing the challenges of pursuing goals that seem ultimately unattainable. Sisyphus embodies the struggle against despair, and his plight serves as a reminder of the value of determination and the quest for meaning, even in apparent pointlessness.