In Egyptian lore, Isis is the wife and sister of Osiris, creating a deep bond between the two deities. After Osiris was killed by his brother Set, Isis searched tirelessly for his body and eventually resurrected him. This act produced their son, Horus, who would later avenge Osiris's death. The relationship between Isis and Osiris embodies themes of death, rebirth, and compassion, reinforcing the significance of family and loyalty in Egyptian mythology.