The Great Schism, which occurred in 1054, was significant in Christian history as it marked the formal split between the Roman Catholic Church and the Eastern Orthodox Church. This schism resulted from a combination of theological disagreements, political conflicts, and cultural differences. Key issues included the role of the Pope, the Filioque clause concerning the Holy Spirit, and various practices and doctrines. The division had profound effects on Christianity, leading to the emergence of distinct religious identities and practices that continue to shape the faith to this day. It also paved the way for future religious reformations and conflicts.