The hormone associated with appetite regulation is leptin, which is produced by adipose (fat) tissue. Leptin informs the brain about energy stores, helping to regulate hunger and energy balance. When fat levels increase, leptin levels rise, signaling satiety and reducing appetite. Conversely, low leptin levels can lead to increased hunger and potential weight gain. Understanding leptin's role can help in managing weight and addressing issues such as obesity, where leptin signaling may be disrupted.