The main health concern related to high saturated fat intake is its association with increased cholesterol levels, leading to a higher risk of heart disease. Saturated fats can elevate low-density lipoprotein (LDL) cholesterol in the bloodstream, contributing to the buildup of arterial plaque. This plaque buildup can restrict blood flow and lead to serious cardiovascular events, such as heart attacks or strokes. It's essential to monitor and manage saturated fat intake to promote heart health, opting instead for unsaturated fats and whole food sources.