Successful long-term weight loss depends on a combination of factors such as maintaining a caloric deficit, adopting a balanced diet, and incorporating regular exercise. A sustainable eating plan, realistic goal setting, and personalized strategies are crucial for adherence. Behavioral changes like mindfulness and self-monitoring can also play significant roles in long-term success. Additionally, having social support and stress management techniques can enhance motivation and prevent weight regain. Lastly, addressing any underlying psychological factors is important for achieving lasting results.