Neglecting physical activity can lead to a range of long-term effects on health, including increased risks of heart disease, obesity, and type 2 diabetes. Lack of exercise contributes to muscle atrophy, reduced bone density, and overall decreased physical performance. It can also lead to mental health issues, such as anxiety and depression, due to lower levels of endorphins and overall decreased physical activity. Furthermore, sedentary behavior is associated with shorter life expectancy and diminished quality of life. Engaging in regular physical activity is essential for maintaining health and well-being over time.