The guidelines for safe weight loss recommend aiming for a gradual loss of about 1 to 2 pounds per week. This approach is generally considered sustainable and safe, minimizing the risk of muscle loss and nutritional deficiencies. Achieving this requires creating a caloric deficit through a combination of diet adjustments and increased physical activity. Adopting a balanced, nutrient-rich diet along with regular exercise can promote healthy weight loss while improving overall wellness and preventing yo-yo dieting.