Factors affecting weight loss beyond diet and exercise include genetic predisposition, hormonal balances, and psychological components. Hormones such as insulin, leptin, and cortisol influence hunger and metabolism, affecting an individual’s ability to lose weight. Additionally, lifestyle factors like stress, sleep quality, and daily activity levels play a critical role in weight management. Psychological aspects, including emotional eating and body image perceptions, significantly impact eating behaviors and motivation. Social support and environmental influences can also sway eating habits. Thus, a comprehensive approach considering these factors is essential for successful weight loss.