Sleep deprivation negatively affects metabolism by disrupting the body's hormonal balance, particularly hormones like ghrelin and leptin that regulate hunger and satiety. Lack of sleep can lead to increased appetite, poor food choices, and reduced energy expenditure. Additionally, sleep deprivation can impair glucose metabolism and insulin sensitivity, increasing the risk of weight gain and metabolic disorders. Prioritizing restful sleep is essential for maintaining a healthy metabolism and optimizing overall health and wellness.