The city located in the Tuscany region of Italy is Florence. Renowned for its art, architecture, and rich history, Florence was the center of the Renaissance, housing masterpieces by artists like Leonardo da Vinci and Michelangelo. The Arno River runs through the city, adding to its picturesque charm. Florence is also famous for its historic landmarks, including the Florence Cathedral and the Uffizi Gallery, making it a key destination for tourists interested in culture and history.