The significance of the Civil Rights Act of 1964 in American history lies in its landmark legislation aiming to eliminate discrimination based on race, color, religion, sex, or national origin. It marked a pivotal moment in the civil rights movement, granting federal enforcement against discrimination in public places, schools, and employment. The act aimed to promote equality and dismantle legal barriers, fostering greater social justice. It also paved the way for further legislation, including the Voting Rights Act of 1965. Ultimately, the Civil Rights Act significantly contributed to advancing civil liberties and enhancing the role of the federal government in promoting equality.