Mother Teresa made profound sacrifices in her pursuit of humanitarian work, including living in extreme poverty and dedicating her life to serving the destitute and dying in Calcutta. She abandoned a comfortable life as a school teacher to follow her calling of helping the poor and ill. Over the years, she established the Missionaries of Charity, which provided shelter, food, and medical care for those in need. Her unwavering commitment often meant she worked long hours under harsh conditions, reflecting her deep sense of compassion and dedication to her mission.