Frances Perkins achieved notable accomplishments as the first female Labor Secretary of the United States, serving under President Franklin D. Roosevelt. She played a crucial role in formulating New Deal policies that transformed labor laws and improved working conditions. Perkins advocated for protections such as the minimum wage, social security, and unemployment insurance. Her efforts were instrumental in establishing a safety net for workers and advancing women's rights in the workforce. Perkins's influence in American labor history remains significant, demonstrating leadership and dedication to social reform.