Stephen Hawking's determination in life was profoundly influenced by his diagnosis of ALS at age 21. Despite facing a progressively debilitating illness, he exhibited remarkable resilience and continued his work in theoretical physics and cosmology. His ability to communicate through a speech-generating device, along with his relentless curiosity about the universe, became iconic. Hawking's struggles inspired many and highlighted the importance of perseverance, making him a symbol of hope for those facing challenges.