Mother Teresa faced numerous challenges in her humanitarian efforts, particularly in Calcutta, where she established the Missionaries of Charity in 1950. Among her most significant obstacles were inadequate resources and health crises, including poverty, disease, and the immense need for basic services among the destitute. Despite facing criticism for her methods and perceived ties to the Catholic Church, she persevered, inspiring many with her commitment to the poor and sick. The rigorous demands of her work underscored the complexities of international humanitarian efforts in politically and socially sensitive environments.