Stephen Hawking's diagnosis of amyotrophic lateral sclerosis (ALS) significantly shaped his scientific contributions and public persona. Given a limited life expectancy, he defied expectations through his groundbreaking work in theoretical physics and cosmology. This diagnosis motivated him to produce influential works, such as "A Brief History of Time," making complex scientific concepts accessible to the public. Despite physical challenges, he utilized assistive technology to communicate and continue his research, thus becoming an inspiring figure in the scientific community. Hawking’s life story highlights the intersection of perseverance, genius, and the human spirit's resilience against adversity.